Calcium carbonate nanoparticles are synthesized using polymer mediated growth technique, a diffusion controlled process where one of the constituting ions is bound within polymer matrix and the other diffuses and reacts to form the desired nanoparticles. Characterization of these synthesized nanoparticles is carried out using X-ray Diffraction, Scanning Electron Microscopy and spectroscopic techniques such as Fourier-Transform Infra-Red spectroscopy and UV-Vis spectroscopy. The diameter of the nanoparticles is estimated to be in the range of 38-40nm. The biocompatibility studies using Reactive Oxygen Species assay, Cell Viability assay and Live/ Dead Cell assay indicated that the nanoparticles show no significant induction of oxidative stress or cell death even at higher concentrations (50�g/ ml) upon exposure to HeLa and LE cells. Here, we report that the synthesized nanosized particles through this technique are safe for biological applications.

Polymer mediated growth of calcium carbonate nanoparticles and their biocompatibility

243rd National Meeting (2012)

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