Breast cancer is the most commonly diagnosed cancer in women. Colorectal cancer is the second leading cause of cancer death in the US. Current detection methods include mammograms, self-exams, colonoscopies, double barium contrast enemas, and digital rectal exams. These methods can be invasive and can only detect the cancer after growths have already formed. For colon cancer, fecal occult blood tests are used to detect blood in the stool, but this screening test is not reliable for cancer diagnosis. We have utilized quantum-dot mesoporous silica composite particles as biosensors in multiplex fluorescence immunoassays. Efforts are focused on encoding mesoporous silica particles with quantum dots of varying ratios to increase the number of target biomarkers that can be screened in a single multiplex assay. This sensitive assay for the multiplexed detection of cancer biomarkers could provide a reliable screening method for early diagnosis of multiple forms of cancer.

Multiplexed detection of cancer biomarkers using quantum dot-mesoporous silica composite particles

243rd National Meeting (2012)

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