Understanding the metabolic behavior of an organism or a living cell is essential for fermentation process. Predictions of metabolic behavior and flux distribution in batch cultures enable better regulation of fermentation in terms of biomass yield and productivity. With the increasing amount of biological knowledge, from genome to metabolome, it becomes relatively straightforward to exploit metabolic and regulatory pathways for fermentation optimization. In this study, a genome-scale model was developed using Pathway Tool and used for systematical analysis of butyric acid fermentation by Clostridium tyrobutyricum. The model was used to study the metabolic pathway in this organism and perform flux analysis to understand the constraint factors of fermentation, optimize the process and improve product yield.  The results from this analysis will be presented in this paper.

Genome-scale model and pathway analysis for optimization of butyric acid fermentation by <i>Clostridium tyrobutyricum</i>

243rd National Meeting (2012)

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Genome-scale model and pathway analysis for optimization of butyric acid fermentation by Clostridium tyrobutyricum