The synthesis of valuable hydrogenation products, many of which are well-established synthetic precursors for the preparation of relevant pharmacologically active compounds, will be disclosed. These compounds have been prepared with excellent enantiomeric excesses using cationic rhodium (I) complexes derived from our set of enantiopure P-OP ligands (phosphine-phosphites).1 The catalytic systems derived from these P-OP ligands provided straightforward access to the hydrogenation products of a-(acylamino)acrylates, itaconic acid derivatives, a-arylenamides and a-aryl enol acetates in high enantioselectivities.2 Amongst other relevant targets, the enantioselective syntheses of key synthetic precursors of levetiracetam, lacosamide, rivastigmine and aprepitant will be reported.  References 1 Fern�ndez-P�rez, H.; Etayo, P.; Panossian, A.; Vidal-Ferran, A. Chem. Rev. 2011  , 111, 2119.2 (a) Fern�ndez-P�rez, H.; Peric�s, M. A.; Vidal-Ferran, A. Adv. Synth. Catal. 2008  , 350, 1984. (b) Donald, S. M. A.; Vidal-Ferran, A.; Maseras, F. Can. J. Chem. 2009  , 87, 1273. (c) Fern�ndez-P�rez, H.; Donald, S. M. A.; Munslow, I. J.; Benet-Buchholz, J.; Maseras, F.; Vidal-Ferran, A. Chem. Eur. J. 2010  , 16, 6495. (d) Fern�ndez-P�rez, H.; Etayo, P.; N��ez-Rico, J. L.; Vidal-Ferran, A. Chim. Oggi 2010  , 28, XXVI. (e) Fern�ndez-P�rez, H.; Donald, S. M. A.; Munslow, I. J.; Benet-Buchholz, J.; Maseras, F.; Vidal-Ferran, A. Chem. Eur. J., in the press.

Application of highly modular P-OP ligands in asymmetric hydrogenation

243rd National Meeting (2012)

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