The development of nonfouling materials and surfaces is critical to many applications, such as biomaterials and biosensors. Polyacrylamide gel has been widely used in SDS-PAGE for protein separation. Nevertheless, the potential of polyacrylamide to be used as surface coatings has barely been explored. In this study, acrylamide was polymerized via atom transfer radical polymerization (ATRP) to form uniform polymer brush on gold surfaces. The superlow fouling properties of the surface-grafted polyacrylamide to resist protein adsorption and cell adhesion were studied. We demonstrate in this work that polyacrylamide grafted surfaces via ATRP highly resist protein adsorption, not only from single protein solutions, but also from 10% and even undiluted serum and plasma. Moreover, polyacrylamide brush highly resists cell adhesion. It is concluded that superlowfouling surfaces with well-controlled polyacrylamide brushes were achieved on gold surfaces.

Superlow fouling polyacrylamide grafted on gold surfaces via atom transfer radical polymerization

243rd National Meeting (2012)

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