Layer-by-layer constructs of conjugated polyelectrolytes have been synthesized by step-wise adsorption of conjugated polyelectrolytes (CPEs) supported on colloidal particles followed by core dissolution; their biocidal activity can be attributed to the CPE's generation of reactive oxygen, and the morphology of the layer-by-layer microcapsules. Differentiating the CPE makeup is of importance for further understanding of not only the mechanism of biocidal activity, but optimizing the given CPE's biocidal efficiency. Template particles were coated with alternating poly(phenylene ethylene)-type conjugated polyelectrolytes followed by dissolution of the inorganic template. Studies of the microcapsules in both light and dark environments, roach motel concentration differentials, bilayer counts, and cationic/anionic pair derivatives were carried out against Staphylococcus epidermidis, Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli. Microcapsules containing an oligomer and a polymer were studied for possible release of oligomer into solution. Strong biocidal activity of the capsules was verified via microscopy and staining procedures.

Light and dark antimicrobials: “Roach motel” synthesis by oligomer/polymer conjugated polyelectrolyte deposition

243rd National Meeting (2012)

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