New ferrocenecarboxylate derivatives were synthesized and biologically examined in vitro with colon cancer cells (HT-29): Ferrocenecarboxylic acid was first activated with oxalyl chloride.  A solution containing the phenolic compound was then added dropwise to the solution containing the acyl chloride.  After extraction, the compound was purified by column chromatography using silica as stationary phase and eluted with dichloromethane (same solvent used in all stages of most of the reactions).  The esters were characterized by FTIR and NMR spectroscopy and the electrochemistry properties were analyzed by cyclic voltammetry. The cytotoxicity studies were performed by the MTT biological assay using HT-29 cells lined. Ferrocene has no significant cytotoxicity, but as moiety in organic molecules, it that can be transported into the cell having anti proliferative effect by its well known redox properties.

New ferrocenecarboxylate derivatives: Synthesis and in vitro antitumor activity study on human colon carcinoma cells (HT-29)

243rd National Meeting (2012)

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