Despite great advances in research and treatment, cancer remains one of the key health concerns in the United States. Efficient drug delivery systems providing therapeutic dose of the drug to the target is a key in development of novel chemotherapy approaches. We present the new type of nanocarrier for hydrophobic and low solubility drugs based on collagen mimetic peptides assembled into triple helix. Triple helix motif lowers enzymatic degradation thus improves bioavailability of the drug. Paclitaxel was use as a model drug conjugated to nanocarrier. The cellular vectors were incorporated into carrier sequence to improve the delivery to nucleus. The effectiveness of the delivery was tested on two cell lines: E6 Jurkats human leukemia cells (FACScan) and NIH-3T3 mice fibroblasts (fluorescent microscopy).

Peptide nanorod: A novel drug carrier

243rd National Meeting (2012)

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