Telomerase is a reverse transcriptase enzyme that adds a specific DNA sequence of repeats (� TTAGGG �) to the 3' end of DNA strands in the telomere regions. Over activity of telomerase in tumor cells draw the researchers attention towards targeting the telomerase as a therapeutic target for cancer.Acridine derivatives are well known for their interaction with human DNA and the enzyme telomerase.  We will present our results in developing a key synthetic procedure for the preparation of a diverse library of acridine derivatives.  The procedure is advancement in the preparation of large nitrogen heterocycles.  It starts with a simple non-air sensitive copper (II) sulfate catalyzed aryl amination of haloarenes, followed by ring closing and additional addition and substitution reactions.

New synthesis approach for the preparation of a diverse library of acridine based telomerase inhibitors

243rd National Meeting (2012)

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