Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is vital to brain and eye function.  Recent investigations established a major role for DHA-derived lipid mediator pathways for the resolution of inflammation and other bioactions.  The development of probes for investigating these pathways as well as for imaging DHA and its metabolites in cells would be valuable for further advances in this area.  Therefore, we have designed and synthesized selected DHA analogs to be used as probes, via a terminal �tag� and click-chemistry. Herein we will report the synthesis of one new analog of this type and describe preliminary studies using 15-lipoxygenase (15-LOX), an enzyme linked to inflammation, showing that this DHA analog is capable of being metabolized in the same way as DHA, and thus may be suitable for cell-based studies.

Docosahexaenoic acid analogs as imaging probes for lipid mediator pathways

243rd National Meeting (2012)

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