Subglutinols A and B are members of the diterpenoid pyrone class of natural immunosuppressive agents isolated from Fusarium subglutinans. To assess their functional mechanisms of immune modulation, the activities of synthetic intermediates of subglutinols A and B were assayed. Subglutnol A and its methyl-g-pyrone derivative, 10,  significantly suppressed IL-2 production by stimulated Jurkat T cells and human and murine CD4+ primary T cells.  These compounds also efficiently inhibited the expression of the T-cell activation markers, CD25 and CD69. Moreover, only compound 10  showed a moderate inhibition of Kv1.3 channel activity. These results indicated that subglutinol structure could be utilized to design new immunosuppressive agents.

Immunosuppressive effects of subglutinol derivatives

243rd National Meeting (2012)

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