A new application for performing scaffold replacements, fragment linking, and R-group optimization is presented. The application is applied to the discovery of novel P38 MAP kinase inhibitors where the diaryl urea core of doramapimod, a known P38 inhibitor, is replaced to produce promising novel candidate inhibitors.

Novel scaffold replacement methodology applied to the discovery of P38 MAP kinase inhibitors

243rd National Meeting (2012)

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