Filamenting temperature-sensitive protein Z (FtsZ), a tubulin homologue, is the most crucial and abundant protein in bacterial cell division. FtsZ polymerizes in the presence of GTP to form a highly dynamic structure, Z-ring. With other several cell division proteins recruitment, Z-ring construction results to septum formation and eventually cell division. Since FtsZ is highly conserved in GTP binding site, inactivation FtsZ preventing Z-ring formation and caused cell elongation which ultimately leads to the cell death. Therefore, FtsZ is an excellent target for the drug discovery of broad-spectrum antibacterial agents against various bacterial pathogens. We will present here novel trisubstituted benzimidazole targeting FtsZ, and their biological activities against F. tularensis, Y. pestis, B. thailandensis, and M. smegmatis.

Synthesis and evaluation of novel trisubstituted benzimidazoles targeting FtsZ as antimicrobial agents

243rd National Meeting (2012)

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