Phosphonates are represented as pharmacophores in various classes of biological agents. Herein we report a straightforward method to synthesis the biological activity of a large class of drug through one step reaction with phosphonate synthons1 under various conditions such as Mitsunobu, acyclic cross-metathesis and nucleophilic substitution. This concept has been validated by the discovery of new antiviral agents.

Convergent synthesis of phosphonate analogs bearing a biolabile moiety

243rd National Meeting (2012)

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