Combination anticancer therapies are more effective than monotherapies, as they improve therapeutic effect and modulate drug resistance. Artemisinin possesses selective superior anticancer activity in numerous cell-lines. CA-4, a potent tubulin inhibitor is active in several cancer cells including MDR positive cells. In consideration of developing potent, selective and bi-functional artemisinin based agents, artemisinin-CA-4 hybrids �artcombs� were synthesised. We will show the design and synthesis of series of novel artcombs and their anticancer effect on both drug sensitive and MDR cells.

Design, synthesis and anticancer activity of artemisinin-combretastatin hybrids

243rd National Meeting (2012)

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