The purpose of a nucleobase in a nucleoside is to hold Watson-Crick base pairing groups and a ribose in the correct relative orientation.  Several nucleoside analogues containing a 1,2,3-triazole-4-carboxamide in place of a purine ring have been prepared.  The anticancer and antiviral activity of some compounds will be presented.

1,2,3-Triazole-4-carboxamide as a nucleobase analog

243rd National Meeting (2012)

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