Evidence suggests isothiocyanates (ITCs) are responsible for the chemoprevention associated with diets rich in cruciferous vegetables. Non-natural ITCs have previously demonstrated enhanced antiproliferation activity versus the natural ITC L-sulforaphane. To elucidate structure-activity trends, a panel of novel ITCs have been synthesized and tested against MCF-7 human breast cancer cells. Preliminary results have identified several key structure-activity relationships that will be useful in developing improved agents.

Sythesis and evaluation of novel isothiocyanates

243rd National Meeting (2012)

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