Oral delivery of peptides such as insulin and PYY  has been successfully achieved by conjugation of these peptides to vitamin B12 (B12), thereby utilizing the dietary uptake pathway for the vitamin.  Intrinsic factor (IF) is a glycoprotein that carries and protects B12 during gastrointestinal passage.  Although this protein serves a critical function in the B12 uptake pathway, up until now, its use as a delivery agent has not directly been explored.  Herein, we describe the site-directed mutagenesis, overexpression, and utilization of IF as a drug delivery agent.

Site-directed mutagenesis of intrinsic factor and its potential use as a drug delivery agent

243rd National Meeting (2012)

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