Current strategies to enhance temporal or spatial control of drug release focus on  incorporating components into the liposome membranes to achieve thermal, pH, photochemical, or enzymatically triggered release.. Light is a very appealing tool for controlling release of active molecules in a spatiotemporally controlled manner due to its direct control and site specificity. Low energy light is preferred in vivo applications due to the low toxicity and deeper tissue penetration To utilize the low energy light for initiating the release, new chemical bonds cleaved by such  low energy light need  to be developed. We designed and prepared a series of substituted olefins as singlet oxygen-mediated cleavable linkers. The substituted olefins were then tested for their reactivity with singlet oxygen using a diode laser.These new olefinic linkers have promising characters  such as facile and high yield synthesis, fast cleavage, and re-generation of parent drug a after the cleavage.

Precise delivery of active molecules(drugs) using diode laser

243rd National Meeting (2012)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.