Synthesis of ten 3-phenyl-5(p-tolyl)-4,5,-dihydro-1H-Pyrazole-carbothioamides have been prepared and characterized by UV-Vis, IR, 1H-NMR,13C-NMR and Mass spectroscopy. All the compounds contained a common pyrazoline nucleus. The titled compounds were investigated for their antioxidant, antimicrobial activity against both Gram positive and Gram negative bacteria and antifungal activity aginst fungal spores like Coliobacterium tricum, Aspergillus niger.The significant antibacterial activity was observed most of the compounds against microorganisms like Bacillus Subtilis and Proteus Vulgaris.  In case of fungi species like Aspergillus niger and Coliobacterium tricum, more activity shown for few compounds. Antioxidant activity is done by measuring IC50 values and it is compared with Ascorbic acid.

Synthesis, characterization, antioxidant and antimicribial activities of some novel pyrazoline derivatives

243rd National Meeting (2012)

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