Sulfones are compounds that have activity against many diseases such as; malaria, tuberculosis, leprosy, HIV; and consequently are highly desirable lead molecules for research. This laboratory prepared amino aryl sulfones through an acid catalyzed rearrangement of a sulfonanilide to a sulfone. This synthesis method provided an easy access to sulfone products. High throughput screening with the Shape Signature program have identified three potential targets for the compounds used; antibacterial, antitumor, and anti-pain (analgesic). This program compares lead molecules to a database of therapeutic ligands based on their shape. This program allows the discovery of new candidate molecule leads for ligands that are based on shape instead of structural likeness. This presentation will involve the synthesis of carbazole, imidostilbene, and imidodibenzyl sulfone and the discovery of new drug targets by Shape Signature. Future work will be to identify, synthesize and assay screening of derivatives of active lead molecules.

Synthesis of heterocyclic aryl sulfones and the investigation of their potential therapeutic uses

243rd National Meeting (2012)

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