While glycosylation is known to govern a multitude of biological events, the tools available to study the activity relationship of specific glycan structures on glycoconjugate and cellular behavior remains limited. In response, we have developed methodology based on chemoselective oxime formation to introduce chemically-defined glycans onto proteins and cell surfaces. This technology centers on an improved synthesis of aminooxy glycans which can be reacted with aldehyde-tagged proteins to create homogeneous glycoproteins or poly-ketone polymers bearing phospholipids for cell membrane insertion. 

Glycoengineering proteins and cell surfaces via synthetic aminooxy glycans

243rd National Meeting (2012)

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