We build branched DNA species joined using sticky ends to produce N-connected objects, lattices and devices. We have made robust 2-state and 3-state sequence-dependent devices that change states by varied hybridization topology. We have constructed a molecular assembly line by combining a DNA origami layer with three 2-state devices, so that there are eight different states represented by their arrangements. We have also self-assembled a 3D crystalline array and have solved its crystal structure to 4 Å resolution, using unbiased crystallographic methods. We can use crystals with two molecules in the crystallographic repeat to  control the color of the crystals. Thus, structural DNA nanotechnology has fulfilled its initial goal of controlling the structure of matter in three dimensions. A new era in nanoscale control awaits us.

Information-based control of molecular structure using DNA

243rd National Meeting (2012)

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