Bioreactor feed strategies are typically developed over a series of experiments using empirical offline data.  Automatic bioreactor sampling and feedback has been applied as a development tool in which cell physiology dynamically determines the nutrient requirements of the culture.  The knowledge gained from this work has then been translated to a less invasive monitoring and feedback system in which platform feed strategies can be quickly defined through the use of biocapacitance sensors and customized bioreactor control code. This work will be discussed in the context of shortening development timelines and improved process optimization.

Application of online bioreactor monitoring and feedback tools for rapid development of better optimized cell culture processes

243rd National Meeting (2012)

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