Orthopedic implants have a 0.5-5.0% bacterial infection rate, often caused by Staphylococcus aureus. These infections typically originate during implantation, but can become symptomatic late (up to 24 months after implantation). The formation of a biofilm, which prevents direct access to the infection, makes it difficult to treat these infections. Long-term controlled release of antibiotics from an orthopedic implant could treat initial infections, avoid late-onset infections, and reduce the amount of systemic antibiotics needed. We have achieved near-linear release for over 45 days using cyclodextrin (CD) crosslinked polymers. One barrier that remains is the application and effect of conventional sterilization techniques, such as autoclaving. Mechanical and chemical changes, such as swelling properties, were investigated to evaluate the effect of the autoclave process on the cyclodextrin-crosslinked polymer. Also changes in the loading capacity and release of antibiotics between autoclaved and nonautoclaved polymer were evaluated.

Evaluation of an autoclaved cyclodextrin affinity-based drug delivery system for orthopedic implant infections

243rd National Meeting (2012)

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