Microalgae are a diverse group of organisms consisting of both prokaryotic and eukaryotic forms. They have extraordinary potential for cultivation as energy crops and are able to produce a wide range of commercially interesting by-products. NRC recently launched a national program to develop novel microalgae cultivation technologies with the long-term aim of converting industrial CO2 emissions into renewable fuels and other value-added products through the commercially scaled production of microalgal biomass. Through this program, a diverse collection of algal strains have been cultivated and tested for their nitric oxide inhibitory activity. MeOH extract of Tetraselmis chuii showed significant reduction of NO production. Further, NO inhibitory activity guided isolation led to identification of two monogalactosyldiacylglycerols (2S)-1-O-(4Z,7,10Z,13Z-hexadecatetranoyl)-2-O-(6Z,9,12Z,15Z-octadecatetranoyl)-3-O-�-D-galactopyranosylglycerol (1  ) and (2S)-1-O-(4Z,7,10Z,13Z-hexadecatetranoyl)-2-O-(9Z,12Z,15Z-octadecatrinoyl)-3-O-�-D-galacto-pyranosylglycerol (2  ). Both MGDGs showed strong NO inhibitory activity. They inhibited NO production through down-regulation of iNOS expression. Structure activity relationship study suggested that PUFA side chain are important for NO inhibition .

Monogalactosyldiacylglycerols: Potent nitric oxide inhibitors from a marine microalgae <i>Tetraselmis chuii</i>

243rd National Meeting (2012)

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Monogalactosyldiacylglycerols: Potent nitric oxide inhibitors from a marine microalgae Tetraselmis chuii