We describe here a strategy to modify the tip of a glass nanopipette with carbohydrate-responsive polymers. Electrical measurements with the device show rapid and reversible response to saccharides and other carbohydrates. The polymers are designed to undergo changes in both charge and hydrophobicity in the presence of saccharides, both of which appear play a role in the sensing mechanism. We will present the characterization of the sensing polymers, incorporation into glass nanopipettes, and performance of the hybrid sensor device.

Carbohydrate sensing with an artificial nanopore

243rd National Meeting (2012)

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