Regioselective modification is a crucial frontier in polysaccharide chemistry. Regioselective synthesis of cellulose derivatives can provide critical understanding of structure-property relationships, analytical characteristics, and biological activity as they relate to polysaccharide nanostructure. We report in this presentation on development of novel synthetic methods for the synthesis of regioselectively modified cellulose derivatives, including 6-amino functionalized cellulose derivatives, some of which have considerable promise in drug delivery by enhancing drug solubility, in nucleic acid delivery by formation of polyelectrolyte complexes, and in tissue engineering by interacting with proteins. We will report on both new methods and new materials that have general promise for enhancing control and understanding of cellulose derivative regiochemistry.

Regioselective synthesis of bioactive cellulose derivatives

243rd National Meeting (2012)

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