Delivery of nucleic acids and proteins into cell is an important and challenging problem. With the help of CSAN's (chemically self-assembled nanostructures), nucleic acids can be specifically targeted to selective cells. We have demonstrated that antisense oligonucleotides for eIF4E (eukaryotic Initiation Factor 4E) can be delivered to cells via surface receptors. Upon endocytosis, oligonucleotides (CSAN's) are released from the endosomes into cytoplasm achieving antisense effect. In the future, this idea will be further extended towards delivery of siRNA and miRNA.

Delivery of nucleic acids and proteins into cells by self-assembling Protein-DNA nanostructures

243rd National Meeting (2012)

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