In this study, aminoethyl-chitooligosaccharide (AE-COS) from COS (below 1 kDa molecular weight) was synthesized and the effect on the proliferation of AGS human gastric adenocarcinoma cells was evaluated and compared. Synthesis of AE-COS from COS was characterized by FT-IR spectroscopy. Treatment with aminoethyl-chitooligosaccharide inhibited cell proliferation in a dose dependent manner. Furthermore, comparing analysis of apoptotic-related gene expression suggests that AE-COS has apoptotic activity by regulating Bcl-2 families responsive genes. Therefore, the present results suggest that aminoethylated COS has inhibitory effect on the proliferation of AGS human gastric adenocarcinoma cells and has promising potential as valuable chemotreventive agents.

Antiproliferative effect of aminoethylated chitooligosaccharide on AGS human gastric cancer cells

243rd National Meeting (2012)

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