A series of cationic calix[4]arene-based lipids with alkyl chains of varying length were newly synthesized and found to form spherical micelles at low pH (protonated state of the amine headgroup) for propyl and hexyl tails. The size monodispersity of the CaL[4]C3 spherical micelles was confirmed with analytical ultracentrifugation, whereas CaL[4]C6 showed polydispersity. From SAXS, static light scattering, and analytical ultracentrifugation, the aggregation numbers for the CaL[4]C3 and CaL[4]C6 spherical micelles were evaluated at 6 and 12, respectively.

Shape-persistent micelles bearing calix[4]arene building block

243rd National Meeting (2012)

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