Organic PET chemistry has evolved into a complex chemical science, and special efforts are focused on the development of rapid, selective and functional group-tolerating reactions with the most prominent short-lived positron emitter fluorine-18 (18F, t1/2 = 109.8 min). The use of catalysts such as transition metal complexes represents a promising approach for rapid and efficient syntheses of a wide variety of 18F-labeled PET radiotracers.Palladium-mediated cross-coupling reactions such as Stille reaction, Suzuki reaction, Sonogashira reaction and N-arylation with various 4-[18F]fluorohalobenzenes as versatile 18F labeling building blocks were shown to be particularly effective reactions. More recently, palladium-mediated nucleophilic 18F-fluorination reactions have further expanded the scope of transition metal complexes in 18F chemistry. The successful application of transition metal complexes was also demonstrated for stereoselective syntheses and functional group transformations of 18F-labeled compounds.In summary, transition metals have significantly advanced and will continue to advance the field of organic PET chemistry with 18F.

Application of transition metals for the synthesis of <sup>18</sup>F-labeled radiotracers

243rd National Meeting (2012)

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Application of transition metals for the synthesis of 18F-labeled radiotracers

Application of transition metals for the synthesis of ¹⁸F-labeled radiotracers