Continuing efforts are made in the development of catalytic asymmetric systems to pyrrolidines due to their unique biological activities as well as their high potential as organocatalysts. Previously, we reported a versatile chiral catalyst system that provided chrial pyrrolidines with orthogonal enantioselectivity under different metal catalysts. In this present poster, we disclose the full detail of copper(I)-catalyzed enantioselective [3 + 2] cycloaddition reactions of glycine imines with a diverse array of alkene derivatives, where high enantio- and diastereoselectivity have been achieved under different chiral copper catalysts derived from a brucine-diol ligand .

Catalytic asymmetric synthesis of pyrrolidines using a diverse chiral copper catalysts derived from a single chiral source

243rd National Meeting (2012)

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