Non-symmetrically substituted phosphorus compounds are omnipresent throughout asymmetric synthesis, both as chiral ligands and in their own right as organocatalysts. Despite their frequent use, the synthesis of such species still remains a challenge. Herein, we report a mild and highly enantioselective route to the preparation of a diverse range of diaryl and dialkyl P-chiral phosphine oxides using the N-phosphoryl oxazolidinone 1  . The application of these P-chiral species as catalysts in a range of asymmetric transformations will also be presented.                                                                                                                    

Enantioselective preparation of <i>P</i>-chiral phosphine oxide organocatalysts and their application in asymmetric synthesis

243rd National Meeting (2012)

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Enantioselective preparation of P-chiral phosphine oxide organocatalysts and their application in asymmetric synthesis