A new catalyst was developed for enantioselective chlorolactonization of olefins. This catalyst was designed based on our previous studies on enantioselective 1,4-syn-bromolactonization of conjugated enynes. The tosyl group connected to the urea part of the catalyst was critical for enantioselectivity. Good yields and enantioselectivity were obtained with various aryl substituted olefins.

Development of catalysts for enantioselective halolactonization of alkenes

243rd National Meeting (2012)

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