Metal-catalyzed asymmetric olefin cyclopropanation with diazo reagents  stands as one of the most general approaches for the synthesis of  optically active cyclopropane derivatives.  Cobalt (II) complexes of  D2-symmetric chiral amidoporphyrins [Co (D2-Por*)] were first introduced  in 2004, now they have emerged as a new class of catalysts for  asymmetric cyclopropanation. These metalloradical catalysts have been  shown to be highly effective for both asymmetric inter- and  intra-molecular cyclopropanation with different classes of carbene  sources, particularly including acceptor/acceptor-substituted diazo  reagents, in excellent diastereoselectivity and enantioselectivity.

Highly asymmetric cyclopropanation reactions by co(II)-based metalloradical catalysis

243rd National Meeting (2012)

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