We have successfully developed dinuclear vanadium(V) complex (Ra,S,S)-1 for enantioselective oxidative coupling of 2-naphthols. Simultaneous activation of two molecules of 2-naphthol by the two vanadium metals in the chiral template led to the smooth homocoupling reaction with high enantiocontrol. This �dual activation� mechanism was supported by kinetic analysis of the catalytic reaction. In this presentation, we will also discuss simple and convenient one-pot preparation of the dinuclear vanadium(V) complex and its application to enantioselective Friedel-Crafts reactions. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/239nm/uploads/13751_bin_acs_2009.jpg' alt='' />

Enantioselective C-C bond-forming reactions using vanadium(V) complexes

243rd National Meeting (2012)

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