A green protocol for the microwave-assisted Hofmann Rearrangement of primary amides mediated by DBDMH and TBD in methanol is described. Under these conditions the methyl carbamates from a wide variety of aliphatic and aromatic amides were obtained in high yields, short reaction times, and excellent purity. This new protocol constitutes a convenient alternative to the traditional method that uses NBS/DBU.

1,3-Dibromo-5,5-dimethylhydantoin and TBD: A sustainable approach to the Hofmann Rearrangement

243rd National Meeting (2012)

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