The N,O-heterocyclic benzoxazole rings are wildly found in many natural products, synthetic pharmaceutical drugs, fluorescence materials and etc. Among the reported data, most methods use a variety of toxic chemical reagents to synthesize such ring. Instead, we report a green pathway  toward the synthesis of the benzoxazole derivatives, which utilizes electrochemical method and avoids the usage of those toxic chemicals. Through intramolecular anodic coupling and combinatorial library synthesis,  a series of benzoxazole derivatives were synthesized efficiently. Detail information and mechanisms studies will be discussed.

Novel green pathway toward the combinatorial library synthesis of benzoxazole derivatives: Utilizing anodic coupling reaction

243rd National Meeting (2012)

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