Isocyanide Multi-component reactions (MCRs) are a powerful transformation in which three or more starting materials are incorporated in a one-pot manner to produce a highly functionalized product. This poster reveals concise, operationally friendly, unique chemical methodology to afford collections of oxazoles in a mere two synthetic operations utilizing the Robinson-Gabriel reaction to form the final oxazole from an appropriately functionalized Ugi product. It is expected the novel two step one pot procedure will be widely embraced in lead generation groups.

Ugi/Robinson-Gabriel reactions directed synthesis of 2, 4, 5-trisubstituted oxazoles

243rd National Meeting (2012)

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