A highly efficient and versatile approach to 2-alkynyl indoles via silver-catalyzed 1-(2-tosylamino)aryl)but-2-yne-1,4-diols is reported herein.1 The novel and non-coupling intramolecular AgOTf-catalyzed reaction offers synthetic route to these diverse heterocycle building blocks in moderate to excellent yields (45-94 %) under mild conditions that does not require metal-catalyzed cross-coupling approach. 

Silver-catalyzed tandem heterocyclization/alkynylation of 1-((2-tosylamino)aryl)but-2-yne-1,4-diols to 2-alkynyl indoles

243rd National Meeting (2012)

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