Preliminary work has demonstrated dimerization for a series of aziridines (1) to symmetrical, substituted benzyl piperazines (2). The addition of benzyl bromide to 2-bromoethylamine hydrobromide in triethylamine led to initial formation of the desired aziridine. This, over time, dimerized to form benzyl piperazines; the presence of both compounds has been confirmed via GC/MS. Continuing efforts include altering variables within the reaction with the intent of preventing the dimerization and isolating the aziridine intermediate as the final product.

Continued studies on the development of a novel synthesis of aziridines

243rd National Meeting (2012)

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