Radical methodologies without the use of alkyltin reagents are increasingly important due to toxicity and difficulty in removing tin by-products from reaction mixtures. This poster highlights an alkyltin-free radical method developed using minimal solvent conditions. This free radical addition process allows for the preparation of a variety of substrates including substituted chromones and coumarins. The method is high yielding, conducted at ambient temperature, and in nearly all instances, classical purification techniques such as chromatography are not needed. It is also shown that the reactions are scalable, giving excellent yields and purities on up to one-gram scales.

Tin-free radical reactions under minimal solvent conditions for the synthesis of substituted chromones and coumarins

243rd National Meeting (2012)

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