Over the past two decades, oxindole based alkaloids have become increasingly appealing targets for total synthesis. 3,3-Substituted oxindole systems are found at the core of numerous natural products, which posses significant medicinal value. Due to the presence of the quaternary center, they are interesting targets for total synthesis. The construction of these core motifs could be achieved using indium mediated Reformatsky reaction. The potential application of this methodology in making novel beta amino acids will also be discussed.

Stereoselective Reformatsky reaction using indium metal: Green chemical routes to oxindole natural products

243rd National Meeting (2012)

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