The thiol-ene click reaction was utilized for the synthesis of dendritic molecules that contain latent reactive groups on the exterior of the molecule. The synthesis was designed with the expectation it would be much more efficient than other dendrimer syntheses. A key synthetic step is the ring opening of a cyclic dithiocarbonate to produce a thiol-terminated intermediate.  Preliminary studies were performed using the anionic and free-radical thiol-ene click reactions with various cyclic dithiocarbonate and glycidyl derivatives.

Efficient synthesis of dendridic pre-cursors via the thiol-ene click reaction

243rd National Meeting (2012)

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