The development of highly multiplexed sequencing reactions via clonal oligonucleotide clusters has provided the means to reduce the cost of sequencing by roughly five orders of magnitude over the last six years. This 'next generation' sequencing has enabled sequencing as a basic tool to inquire the state of DNA variation, the transcriptional levels of the multitude of RNAs, the location of transcriptional cofactors, and many other molecular characteristics that can be expressed as an oligonucleotide. This presentation will summarize the technology and showcase several vignettes of current biological and medical interest.

Next generation sequencing: Redefining growth beyond Moore's Law

243rd National Meeting (2012)

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