Parnafungin A (1 ), isolated from the fungus Fusarium larvarum,<i>   implies both, a tetrahydroxanthone 2  as well as an isoxazolidinone core 3 .For the total synthesis of Parnafungin A (1 ) it is planned build up the tetrahydroxanthone core 6  via a domino oxa-Michael-aldol reaction with the functionalized salicylaldehyde 5  and cyclohexenone 4  . After oxidation in benzylic position and hydrogenation of the carbon-nitrogen-bond, we want to finish the total synthesis of Parnafungin A (1  ) by ring-closure of the isoxazolidinone cycle and subsequent deprotection.<i> Overy, D.  Bioorg. Med. Chem. Lett. 2009  , 19, 1224�1227.

Towards the total synthesis of Parnafungin A

243rd National Meeting (2012)

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