Galtamycin (1 ) is a member of the angucycline family of antitumor antibiotics and displays cytotoxicity against Gram-positive bacteria, human cytomegalovirus, and certain carcinomas.  Structurally, galtamycin (1 ) consists of a polyketide-derived tetracycle adorned with a highly deoxygenated tetrasaccharide unit attached via a 2-deoxy-�-C-aryl glycosidic linkage.  As part of our program aimed at the development of architecturally novel chemotherapeutic agents based upon natural product scaffolds, we will present our progress toward the construction of the aromatic core of 1 .

Synthetic investigations toward the angucycline antitumor antibiotic galtamycin

243rd National Meeting (2012)

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