The first total synthesis of the indole alkaloid subincanadine E is reported in a 10-step sequence from tryptamine. This natural product was first isolated from Picralima nitida cell suspension cultures by Lim and co-workers in 1982 under the name pericine and again in 2002 by Kobayashi as subincanadine E from Aspidosperma subincanum. It is the most biologically potent member of the subincanadine family of alkaloids with in vitro toxicity against both lymphoma and carcinoma cell lines (LD50 = 0.3 �g/mL and 4.4 �g/mL, respectively). 

Total synthesis of the <i>Aspidosperma </i>indole alkaloid subincanadine E

243rd National Meeting (2012)

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Total synthesis of the Aspidosperma indole alkaloid subincanadine E