Oxindole and its derivatives are abundant in many natural substances and endogeneous to mammals and plants. Oxindole core is found in numerous biologically relevant compounds exhibiting broad spectrum of activity. 3-substituted-3-hydroxy oxindoles are found in numerous targets. The presence of the quaternary stereo-center at the 3-position has generated significant attention of the synthetic chemist for the past decade. A direct approach for the motif is nucleophilic addition to isatin. Recently we have developed enantioselective methodologies based on indium and bismuth metal for the construction of the quaternary center.

Progress towards total synthesis of 3-allyl-3-hydroxy oxindole natural products

243rd National Meeting (2012)

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